H-Cube Maxi™ - Production Synthesis Without Limitations
ThalesNano have developed a product line that can handle flow chemistry and/or catalyst screening from milligramme scale to Tonnes/annum. The new H-Cube Maxi™, is the next generation of the H-Cube® technology and is a production scale continuous process hydrogenation system. The GMP-Ready H-Cube Maxi™ is a continuous flow production scale chemistry platform designed to perform hydrogenation and other heterogeneously catalyzed reactions.
With the H-Cube Maxi™, process scale chemists can now access new and previously restricted chemistries or improve on existing processes by reducing side product formation- leading to a reduction in downstream waste generation.
When utilized in conjunction with ThalesNano’s other bench-scale reactors, such as the H-Cube® and H-Cube Midi™, chemists can realize continuous processing from milligrams to kilo scale production, quickly without the need for reoptimization. When used continuously, the H-Cube Maxi™ can generate tonnes of API per annum.
The harmonized product line and technology that covers a wide range of scale can provide great advantage to customers over traditional batch based technologies.
H-Cube Maxi™ Specification (custom specifications are also accepted)
- Reactor Temperature Range: Room temperature to 350°C (± 1%)
- Reaction line temperature range: Room temperature to 80°C for viscous liquids.
- Maximum Pressure: 130 bar (± 1%)
- Liquid Flow Rate Range: 0.1 - 50 mL/min
- Gas Flow Rate Range: 10 - 1000 cm3/min
- Number of Independent Gas Lines: 3
- Catalyst bed dimensions: 30mm ID x 900 mm
- Duty and Standby Column for continuous processing
- Possibility to pack your own catalyst
Advantages
- Faster Scale Up: Faster optimization and less resource intensive.
- High temperature and pressure range: React even the most difficult substrates.
- High temperature control: Less side products generated meaning higher yields and less waste.
- Uninterrupted production: Two columns allow 24 hr continuous processing.
- Small footprint with high throughput capabilities: Maximise your space.
- No catalyst filtering: Safer and less process intensive
- Reduces purge gas emissions and volatiles: Less waste production. Greener chemistry.
- Low reaction volume: Reduced chance of runaway exothermic reactions
- Simpler to operate: Less resource intensive
The H-Cube Maxi™ will provide process chemists the same advantages of speed, safety and high yields that their medicinal chemistry colleagues already enjoy when using ThalesNano’s benchtop products.
ThalesNano is already taking orders for the system. For further information, contact sales@thalesnano.com.