X-Cube™

The X-Cube™ is a state of the art flow reactor produced by ThalesNano Inc.
Following on from the award winning H-Cube®, the X-Cube™ broadens the scope of the way organic synthesis is performed.

The X-Cube™ allows organic reactions to be performed in a flow manner, combining the use of temperatures and pressures up to 200°C (392°F) and 150 bar (2176 psi) respectively and catalyst/reagent cartridge system (CatCart®).

Key Features

A continuous-flow of reaction mixture may be fed by a dual pump system or injected into the reactor directly.
Once in the system, the reaction mixture is heated, pressurized and passed through a reagent or catalyst cartridge. All reagents are heterogeneous including many polymer bound reagents and catalysts.
The product is generated and pumped continuously out of the system into a collector.

The large selection of reagent and catalyst cartridges, available through ThalesNano Inc., allows a wide variety of reactions to be performed on the X-Cube™, including:

Suzuki, Sonogashira and Heck couplings
Buchwald reaction
Halogenation
Amine displacement
Alkylation
Dehydration
Esterification
Azide formation

The range of solid supported reagents and catalysts are continually being investigated and expanded.

Advantages

Adaptable

Reactions can be heated and/or cooled on the same reactor.
X-Cube™ can be combined with other X-Cube™ or H-Cube® flow reactors for multistep synthesis in one flow through.
Capable of integration into liquid handling equipment for full automation.

Scalable

Reactions can be easily scaled from mg to grams to kilos by using 1 reactor or many reactors in parallel.

Efficient

The high pressure / high temperature capability means many reactions progress to completion in minutes.
Reactions may be optimized "on the fly" to obtain optimum reaction conditions in minutes.

Safe

Low volume system with high temperature control meaning many volatile reactions can be safely and at high pressure.

X-Cube flow reactor

1. Touch-screen panel	2. Heater	3. Back-pressure system	4. Dual pump and injection system
Every operational step of the X-Cube™ is controlled using a touch-screen panel. Parameters such as temperature, pressure, flow-rate and injection cam all be controlled using the touch-screen. Parameters can be changed on the fly.	The X-Cube™ is capable of heating the reaction mixture up to 200°C (392°F). The low volume of the reaction line means heating the reaction up to temperature takes seconds and temperature control is very precise.	The X-Cube™ is capable of pressurizing reaction mixture up to 150 bar (2176 psi)	Reagents can be introduced via single, dual pump control or via syringe injecti

X-Cube™ Brochure [1]

X-Cube™ Application Note - Coupling Reactions [2]

X-Cube™ Application Notes - General Reactions [3]